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Can I read Ankycorbin: a Novel Actin Cytoskeleton-associated Protein on EtoBox?
Ankycorbin: a Novel Actin Cytoskeleton-associated Protein by Ying-Feng Peng; Kenji Mandai; Toshiaki Sakisaka; Noriko Okabe; Yasunori Yamamoto; Shigekazu Yokoyama; Akira Mizoguchi; Hitoshi Shiozaki; Morito Monden; Yoshimi Takai is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Ankycorbin: a Novel Actin Cytoskeleton-associated Protein about?
Actin cytoskeleton structures are essential for a wide variety of cell functions, including cell shape change, cell motility, cell adhesion, cell polarity and cytokinesis. Many actin filament (F‐actin)‐binding proteins have been isolated and implicated in the maintenance and reorganization of actin cytoskeleton structures. We purified here a novel protein with a molecular mass of about 125 kDa (p125) from rat liver. We cloned its cDNA from a mouse kidney cDNA library and determined its nucleotide and deduced amino acid sequences. p125 was a protein of 979 amino acids with a calculated __M__~r~ of 108 847. p125 contained six ankyrin repeats in the N‐terminal region and a domain predicted to form a coiled‐coil structure in the C‐terminal region. We named p125 ankycorbin (ankyrin repeat‐ and coiled‐coil structure‐containing protein). Northern blot analysis indicated that ankycorbin was ubiquitously expressed in all the tissues examined. Immunofluorescence and immunoelectron microscope analyses revealed that ankycorbin was associated with the cortical actin cytoskeleton structures in terminal web and cell‐cell adhesion sites and stress fibres. However, ankycorbin did not directly bind
Who reads Ankycorbin: a Novel Actin Cytoskeleton-associated Protein?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ying-Feng Peng; Kenji Mandai; Toshiaki Sakisaka; Noriko Okabe; Yasunori Yamamoto; Shigekazu Yokoyama; Akira Mizoguchi; Hitoshi Shiozaki; Morito Monden; Yoshimi Takai
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)