Opening book details…
Can I read Effects of Verapamil and Nifedipine on Renal Function and Hemodynamics in the Dog on EtoBox?
Effects of Verapamil and Nifedipine on Renal Function and Hemodynamics in the Dog by Bell, Anthony J.; Lindner, Armando is a Medicine article available to read on EtoBox.
What is Effects of Verapamil and Nifedipine on Renal Function and Hemodynamics in the Dog about?
This study evaluates the direct effects of verapamil (5 μg/kg/min) or nifedipine (0.32 μg/kg/min) when infused into one renal artery for 2 h. The role of calcium in the systemic and renal vascular effects of angiotensin II (1 μg/i.v.bolus) was examined in each period.Renal blood flow was increased 11% by verapamil and 29% by nifedipine. Unlike other vasodilators, these drugs markedly increased GFR (by 75% with verapamil and 50% with nifedipine), and both caused a profound natriuresis, which outlasted the renal hemodynamic changes. Further, they abolished the renal vascular responses to angiotensin II. These major direct effects on renal function and hemodynamics suggest that: (a) calcium blockers may affect the determinants of GFR differently from other vasodilators, and (b) they may interfere with proximal tubular Na^+^ transport.
Who reads Effects of Verapamil and Nifedipine on Renal Function and Hemodynamics in the Dog?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Bell, Anthony J.; Lindner, Armando
- Publisher
- S. Karger AG (ISSN 1420-4096)
- Published
- 1984
- Language
- EN
- Field
- Medicine (Health Sciences)