About this Medicine article

Comparison Of The Efficacy Of New And Conventional Antipsychotic Drugs In The Treatment Of Behavioral And Psychological Symptoms Of Dementia (bpsd) by P. GARERI; A. COTRONEO; R. LACAVA; G. SEMINARA; N. MARIGLIANO; A. LOIACONO; G. DE SARRO is a Medicine article available to read on EtoBox.

## SUM MARY This double-blind study evaluated the efficacy and safety of risperidone or olanzapine vs. promazine in the treatment of behavioral and psychological symptoms in dementia (BPSD). Patients were required to be 65 years or older, to have DSM-IV diagnoses of Alzheimer's disease (AD), vascular dementia (VD) or a combination of both. A brain computerized tomography (CT) was performed for all the patients; 60 demented patients, 27 men (45 %) and 33 women (55 %) were selected for this study. The University of California Los Angeles neuropsychiatric inventory (NPI) was administered at baseline, then after 4 and 8 weeks. Patients had at least a score of 24 or more. The Hoehn and Yahr scale was used for evaluating parkinsonism. The scales were administered by an examinator who was not aware of the kind of treatment of the patients. After a wash-out period of 10 days, 20 patients, 9 men and 11 women, mean age 76.6 ± 6.0 years, were randomly assigned to risperidone 1 mg daily in divided doses (morning and bedtime) (Group A); 20 patients, 9 men and 11 women, mean age 82.5 ± 9.3 years were randomly assigned to olanzapine 5 mg at bedtime (Group B), and 20 patients, 9 men and 11 women,

Author

P. GARERI; A. COTRONEO; R. LACAVA; G. SEMINARA; N. MARIGLIANO; A. LOIACONO; G. DE SARRO

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0167-4943)

Published

2004

Language

EN

Field

Medicine (Health Sciences)