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“Omics” in traumatic brain injury: novel approaches to a complex disease by Sami Abu Hamdeh; Olli Tenovuo; Wilco Peul; Niklas Marklund is a Medicine article available to read on EtoBox.

What is “Omics” in traumatic brain injury: novel approaches to a complex disease about?

## Background To date, there is neither any pharmacological treatment with efficacy in traumatic brain injury (TBI) nor any method to halt the disease progress. This is due to an incomplete understanding of the vast complexity of the biological cascades and failure to appreciate the diversity of secondary injury mechanisms in TBI. In recent years, techniques for high-throughput characterization and quantification of biological molecules that include genomics, proteomics, and metabolomics have evolved and referred to as omics. ## Methods In this narrative review, we highlight how omics technology can be applied to potentiate diagnostics and prognostication as well as to advance our understanding of injury mechanisms in TBI. ## Results The omics platforms provide possibilities to study function, dynamics, and alterations of molecular pathways of normal and TBI disease states. Through advanced bioinformatics, large datasets of molecular information from small biological samples can be analyzed in detail and provide valuable knowledge of pathophysiological mechanisms, to include in prognostic modeling when connected to clinically relevant data. In such a complex disease as TBI, omics e

Who reads “Omics” in traumatic brain injury: novel approaches to a complex disease?

Author

Sami Abu Hamdeh; Olli Tenovuo; Wilco Peul; Niklas Marklund

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)