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Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene, Xylene, and Formaldehyde in Mice by Asaka Saito; Hiroyuki Tanaka; Haruki Usuda; Tomonori Shibata; Sayaka Higashi; Hirotaka Yamashita; Naoki Inagaki; Hiroichi Nagai is a Environmental Science article available to read on EtoBox.

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## Abstract Volatile organic compounds (VOCs) are considered the main cause of sick building syndrome and they are likely to irritate the skin, eyes, and mucous membrane; however, the toxic threshold and the mechanisms of cutaneous reaction induced by long‐time VOC exposure have not been clarified. In the present study, we investigated the effect of repeated painting of VOCs onto mouse skin. Various concentrations of toluene, xylene, and formaldehyde (FA) were applied once a week for 5 weeks. While FA solution (2–10%) induced remarkable ear swelling and caused evident infiltration of inflammatory cells, high concentrations of toluene and xylene (50 or 100%) evoked mild ear swelling and marginal inflammatory cell invasion. In addition, FA exposure markedly increased the expression of interleukin‐4 (IL‐4), brain‐derived neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3), and transient receptor potential vanilloid‐1 (TRPV‐1) mRNAs in the ears and IL‐4 and NT‐3 mRNAs in the cervical lymph nodes. Furthermore, capsazepine, a TRPV‐1 antagonist, significantly suppressed ear swelling caused by repeated painting of 5% FA. These findings demonstrate that FA has more potent irritancy against sk

Who reads Characterization of Skin Inflammation Induced by Repeated Exposure of Toluene, Xylene, and Formaldehyde in Mice?

Author

Asaka Saito; Hiroyuki Tanaka; Haruki Usuda; Tomonori Shibata; Sayaka Higashi; Hirotaka Yamashita; Naoki Inagaki; Hiroichi Nagai

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)

Published

2011

Language

EN

Field

Environmental Science (Physical Sciences)