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Integrated Genomic and Transcriptional Profiling Identifies Chromosomal Loci with Altered Gene Expression in Cervical Cancer by Saskia M. Wilting; Jillian de Wilde; Chris J. L. M. Meijer; Johannes Berkhof; Yajun Yi; Wessel N. van Wieringen; Boudewijn J. M. Braakhuis; Gerrit A. Meijer; Bauke Ylstra; Peter J. F. Snijders; Renske D. M. Steenbergen is a Medicine article available to read on EtoBox.
What is Integrated Genomic and Transcriptional Profiling Identifies Chromosomal Loci with Altered Gene Expression in Cervical Cancer about?
## Abstract For a better understanding of the consequences of recurrent chromosomal alterations in cervical carcinomas, we integrated genome‐wide chromosomal and transcriptional profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and 6 normal controls. Previous genomic profiling showed that gains at chromosome arms 1q, 3q, and 20q as well as losses at 8q, 10q, 11q, and 13q were common in cervical carcinomas. Altered regions spanned multiple megabases, and the extent to which expression of genes located there is affected remains unclear. Expression analysis of these previously chromosomally profiled carcinomas yielded 83 genes with significantly differential expression between carcinomas and normal epithelium. Application of differential gene locus mapping (DIGMAP) analysis and the array CGH expression integration tool (ACE‐it) identified hotspots within large chromosomal alterations in which gene expression was altered as well. Chromosomal gains of the long arms of chromosome 1, 3, and 20 resulted in increased expression of genes located at 1q32.1‐32.2, 3q13.32‐23, 3q26.32‐27.3, and 20q11.21‐13.33, whereas a chromosomal loss of 11q22.3‐25 was related to decrea
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- Author
- Saskia M. Wilting; Jillian de Wilde; Chris J. L. M. Meijer; Johannes Berkhof; Yajun Yi; Wessel N. van Wieringen; Boudewijn J. M. Braakhuis; Gerrit A. Meijer; Bauke Ylstra; Peter J. F. Snijders; Renske D. M. Steenbergen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Life Sciences)