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Can I read Derivative Spectrophotometric Analysis of Benzophenone (as an Impurity) in Phenytoin on EtoBox?
Derivative Spectrophotometric Analysis of Benzophenone (as an Impurity) in Phenytoin by Mohamed Ibrahim Walash; Mohamed Salem Rizk; Zeinab Awad Sheribah; Mohamed Mansour Salim is a Chemistry article available to read on EtoBox.
What is Derivative Spectrophotometric Analysis of Benzophenone (as an Impurity) in Phenytoin about?
Three simple and rapid spectrophotometric methods were developed for detection and trace determination of benzophenone (the main impurity) in phenytoin bulk powder and pharmaceutical formulations. The first method, zero-crossing first derivative spectrophotometry, depends on measuring the first derivative trough values at 257.6 nm for benzophenone. The second method, zero-crossing third derivative spectrophotometry, depends on measuring the third derivative peak values at 263.2 nm. The third method, ratio first derivative spectrophotometry, depends on measuring the peak amplitudes of the first derivative of the ratio spectra (the spectra of benzophenone divided by the spectrum of 5.0 μg/mL phenytoin solution) at 272 nm. The calibration graphs were linear over the range of 1-10 μg/mL. The detection limits of the first and the third derivative methods were found to be 0.04 μg/mL and 0.11 μg/mL and the quantitation limits were 0.13 μg/mL and 0.34 μg/mL, respectively, while for the ratio derivative method, the detection limit was 0.06 μg/mL and the quantitation limit was 0.18 μg/mL. The proposed methods were applied successfully to the assay of the studied drug in phenytoin bulk powder
Who reads Derivative Spectrophotometric Analysis of Benzophenone (as an Impurity) in Phenytoin?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Mohamed Ibrahim Walash; Mohamed Salem Rizk; Zeinab Awad Sheribah; Mohamed Mansour Salim
- Publisher
- Chemistry Central; Springer (Biomed Central Ltd.); London: Chemistry Central Ltd. in association with BioMed Central, c2007-2018.; Springer Science and Business Media LLC (ISSN 1752-153X)
- Published
- 2011
- Language
- EN
- Field
- Chemistry (Physical Sciences)