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Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum by Craig H. Steeves; Joanna Potrykus; David A. Barnett; Stephen L. Bearne is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum about?

## Abstract The anaerobic, Gram‐negative bacillus __Fusobacterium nucleatum__ plays a vital role in oral biofilm formation and the development of periodontal disease. The organism plays a central bridging role between early and late colonizers within dental plaque and plays a protective role against reactive oxygen species. Using a two‐dimensional gel electrophoresis and mass spectrometry approach, we have annotated 78 proteins within the proteome of __F. nucleatum__ subsp. __nucleatum__ and identified those proteins whose apparent intracellular concentrations change in response to either O~2~‐ or H~2~O~2~‐induced oxidative stress. Three major protein systems were altered in response to oxidative stress: (i) proteins of the alkyl hydroperoxide reductase/thioredoxin reductase system were increased in intracellular concentration; (ii) glycolytic enzymes were modified by oxidation (i.e. D‐glyceraldehyde 3‐phosphate dehydrogenase, and fructose 6‐phosphate aldolase) or increased in intracellular concentration, with an accompanying decrease in ATP production; and (iii) the intracellular concentrations of molecular chaperone proteins and related proteins (i.e. ClpB, DnaK, HtpG, and HrcA)

Who reads Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum?

Author

Craig H. Steeves; Joanna Potrykus; David A. Barnett; Stephen L. Bearne

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)