Opening book details…
Can I read Predictive Biomarkers for 5-Fluorouracil and Oxaliplatin-based Chemotherapy in Gastric Cancers via Profiling of Patient-derived Xenografts on EtoBox?
Predictive Biomarkers for 5-Fluorouracil and Oxaliplatin-based Chemotherapy in Gastric Cancers via Profiling of Patient-derived Xenografts by Deukchae Na; Jeesoo Chae; Sung-Yup Cho; Wonyoung Kang; Ahra Lee; Seoyeon Min; Jinjoo Kang; Min Jung Kim; Jaeyong Choi; Woochan Lee; Dongjin Shin; Ahrum Min; Yu-Jin Kim; Kyung-Hun Lee; Tae-Yong Kim; Yun-Suhk Suh; Seong-Ho Kong; Hyuk-Joon Lee; Woo-Ho Kim; Hansoo Park; Seock-Ah Im; Han-Kwang Yang; Charles Lee; Jong-Il Kim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Predictive Biomarkers for 5-Fluorouracil and Oxaliplatin-based Chemotherapy in Gastric Cancers via Profiling of Patient-derived Xenografts about?
Gastric cancer (GC) is commonly treated by chemotherapy using 5-fluorouracil (5-FU) derivatives and platinum combination, but predictive biomarker remains lacking. We develop patient-derived xenografts (PDXs) from 31 GC patients and treat with a combination of 5-FU and oxaliplatin, to determine biomarkers associated with responsiveness. When the PDXs are defined as either responders or non-responders according to tumor volume change after treatment, the responsiveness of PDXs is significantly consistent with the respective clinical outcomes of the patients. An integrative genomic and transcriptomic analysis of PDXs reveals that pathways associated with cell-to-cell and cell-to-extracellular matrix interactions enriched among the non-responders in both cancer cells and the tumor microenvironment (TME). We develop a 30-gene prediction model to determine the responsiveness to 5-FU and oxaliplatin-based chemotherapy and confirm the significant poor survival outcomes among cases classified as non-responder-like in three independent GC cohorts. Our study may inform clinical decision-making when designing treatment strategies.
Who reads Predictive Biomarkers for 5-Fluorouracil and Oxaliplatin-based Chemotherapy in Gastric Cancers via Profiling of Patient-derived Xenografts?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Deukchae Na; Jeesoo Chae; Sung-Yup Cho; Wonyoung Kang; Ahra Lee; Seoyeon Min; Jinjoo Kang; Min Jung Kim; Jaeyong Choi; Woochan Lee; Dongjin Shin; Ahrum Min; Yu-Jin Kim; Kyung-Hun Lee; Tae-Yong Kim; Yun-Suhk Suh; Seong-Ho Kong; Hyuk-Joon Lee; Woo-Ho Kim; Hansoo Park; Seock-Ah Im; Han-Kwang Yang; Charles Lee; Jong-Il Kim
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)