Can I read A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke on EtoBox?

A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke by Qian Cui; Yu-liang Zhang; Yu-hui Ma; Hao-yu Yu; Xin-zhe Zhao; Li-hui Zhang; Shao-qin Ge; Guo-wei Zhang; Xiu-de Qin is a Agricultural and Biological Sciences article available to read on EtoBox.

What is A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke about?

## Ethnopharmacological relevance: Shuxuening injection (sxni), a popular herbal medicine, is an extract of ginkgo biloba leaves (gbe), and is used to treat ischemic stroke (is) in china. however, its specific active ingredients and molecular mechanisms in is remain unclear. ## Aim of the study: The purpose of the research is to identify the main active ingredients in gbe and explore its molecular mechanisms in the treatment of is. ## Materials and methods: The main active components of gbe were discerned through the traditional chinese medicine systems pharmacology database and analysis (tcmsp), traditional chinese medicine integrated database (tcmid), bioinformatics analysis tool for molecular mechanism of traditional chinese medicine (batman-tcm) database, and absorption, distribution, metabolism and excretion (adme) analysis. the targets related to is were obtained using genecards, online mendelian inheritance in man (omim), therapeutic target database (ttd), and disgenet. we discovered an intersection of genes. subsequently, protein-protein interaction (ppi) networks were constructed with cytoscape 3.7.1 and the string database. gene ontology (go) and kyoto encyclopedia of gen

Who reads A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke?

Author

Qian Cui; Yu-liang Zhang; Yu-hui Ma; Hao-yu Yu; Xin-zhe Zhao; Li-hui Zhang; Shao-qin Ge; Guo-wei Zhang; Xiu-de Qin

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-8741)

Published

2020

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)