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Development of the Avian Lymphatic System by Jörg Wilting; Maria Papoutsi; Karim Othman‐Hassan; Marc Rodriguez‐Niedenführ; Felicitas Pröls; Stanislav I. Tomarev; Anne Eichmann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Development of the Avian Lymphatic System about?

## Abstract Recently, highly specific markers of the lymphatic endothelium have been found enabling us to reinvestigate the embryonic origin of the lymphatics. Here we present a review of our studies on the development of the lymphatic system in chick and quail embryos. We show that the lymphatic endothelium is derived from two sources: the embryonic lymph sacs and mesenchymal lymphangioblasts. Proliferation studies reveal a BrdU‐labeling index of 11.5% of lymph sac endothelial cells by day 6.25, which drops to 3.5% by day 7. Lymphangioblasts are able to integrate into the lining of lymph sacs. Lymphatic endothelial cells express the vascular endothelial growth factor (VEGF) receptors‐2 and ‐3. Their ligand, VEGF‐C, is expressed almost ubiquitously in embryonic and fetal tissues. Elevated expression levels are found in the tunica media of large blood vessels, which usually serve as major routes for growing lymphatics. The homeobox gene, __Prox1__, is expressed in lymphatic but not in blood vascular endothelial cells throughout all stages examined, namely, in developing lymph sacs of day 6 embryos and in lymphatics at day 16. Experimental studies show the existence of lymphangioblas

Who reads Development of the Avian Lymphatic System?

Author

Jörg Wilting; Maria Papoutsi; Karim Othman‐Hassan; Marc Rodriguez‐Niedenführ; Felicitas Pröls; Stanislav I. Tomarev; Anne Eichmann

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1059-910X)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)