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PHROG: families of prokaryotic virus proteins clustered using remote homology by Paul Terzian; Eric Olo Ndela; Clovis Galiez; Julien Lossouarn; Rubén Enrique Pérez Bucio; Robin Mom; Ariane Toussaint; Marie-Agnès Petit; François Enault is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is PHROG: families of prokaryotic virus proteins clustered using remote homology about?

## Abstract Viruses are abundant, diverse and ancestral biological entities. Their diversity is high, both in terms of the number of different protein families encountered and in the sequence heterogeneity of each protein family. The recent increase in sequenced viral genomes constitutes a great opportunity to gain new insights into this diversity and consequently urges the development of annotation resources to help functional and comparative analysis. Here, we introduce PHROG (Prokaryotic Virus Remote Homologous Groups), a library of viral protein families generated using a new clustering approach based on remote homology detection by HMM profile-profile comparisons. Considering 17 473 reference (pro)viruses of prokaryotes, 868 340 of the total 938 864 proteins were grouped into 38 880 clusters that proved to be a 2-fold deeper clustering than using a classical strategy based on BLAST-like similarity searches, and yet to remain homogeneous. Manual inspection of similarities to various reference sequence databases led to the annotation of 5108 clusters (containing 50.6 % of the total protein dataset) with 705 different annotation terms, included in 9 functional categories, specifi

Who reads PHROG: families of prokaryotic virus proteins clustered using remote homology?

Author

Paul Terzian; Eric Olo Ndela; Clovis Galiez; Julien Lossouarn; Rubén Enrique Pérez Bucio; Robin Mom; Ariane Toussaint; Marie-Agnès Petit; François Enault

Publisher

Oxford University Press (OUP)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)