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Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis by Joseph A. Garcia; Rui Chen; Min Xu; Sarah A. Comerford; Robert E. Hammer; Shelby D. Melton; Linda A. Feagins is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis about?

The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1 (Sirt1), and Hypoxia Inducible Factor 2α (HIF-2α). We previously shown in mice that exogenous acetate augments growth and metastasis of flank tumors derived from fibrosarcoma-derived HT1080 cells in an Acss2/HIF-2 dependent manner. Colonic epithelial cells are exposed to the highest acetate levels in the body. We reasoned that colon cancer cells, like fibrosarcoma cells, may respond to acetate in a pro-growth manner. In this study, we examine the role of Acss2/HIF-2 signaling in colon cancer. We find that Acss2/HIF-2 signaling is activated by oxygen or glucose deprivation in two human colon cancer-derived cell lines, HCT116 and HT29, and is crucial for colony formation, migration, and invasion in cell culture studies. Flank tumors derived from HCT116 and HT29 cells exhibit augmented growth in mice when supplemented with exogenous acetate in an Acss2/HIF-2 dependent manner. Finally, Acss2 in human colon cancer samples is most frequently

Who reads Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis?

Author

Joseph A. Garcia; Rui Chen; Min Xu; Sarah A. Comerford; Robert E. Hammer; Shelby D. Melton; Linda A. Feagins

Publisher

Public Library of Science (PLoS)

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)