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Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients by Chaoyang Sun; Yuzhe Sun; Ping Wu; Wencheng Ding; Shiyou Wang; Jiafeng Li; Langchao Liang; Chaochao Chai; Yu Fu; Zhiming Li; Linnan Zhu; Jia Ju; Xin Liao; Xiaoyuan Huang; Ling Feng; Ding Ma; Liang He; Dongsheng Chen; Gang Chen; Xin Jin; Peng Wu is a Medicine article available to read on EtoBox.
What is Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients about?
## Abstract ## Purpose Critically ill COVID-19 patients have significantly increased risk of death. Although several circulating biomarkers are thought to be related to COVID-19 severity, few studies have focused on the characteristics of critically ill patients with different outcomes. The objective of this study was to perform a longitudinal investigation of the potential mechanisms affecting the prognosis of critically ill COVID-19 patients. ## Methods In addition to clinical data, 113 whole blood samples and 85 serum samples were collected from 33 severe and critical COVID-19 patients without selected comorbidities. Multi-omics analysis was then performed using longitudinal samples. ## Results Obvious transcriptional transitions were more frequent in critical survivors than in critical non-survivors, indicating that phase transition may be related to survival. Based on analysis of differentially expressed genes during transition, the erythrocyte differentiation pathway was significantly enriched. Furthermore, clinical data indicated that red blood cell counts showed greater fluctuation in survivors than in non-survivors. Moreover, declining red blood cell counts and hemoglobin
Who reads Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chaoyang Sun; Yuzhe Sun; Ping Wu; Wencheng Ding; Shiyou Wang; Jiafeng Li; Langchao Liang; Chaochao Chai; Yu Fu; Zhiming Li; Linnan Zhu; Jia Ju; Xin Liao; Xiaoyuan Huang; Ling Feng; Ding Ma; Liang He; Dongsheng Chen; Gang Chen; Xin Jin; Peng Wu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)