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Cost‐effectiveness analysis of dinutuximab β for the treatment of high‐risk neuroblastoma in China by An‐Le Shen; Jie Zhao; Li‐Ting Yu; An‐An Zhang; Bin Wu; Ye Fang; Ya‐Li Han; Chen‐Sui‐Zi Li; Zhi‐Ling Li; Yi‐Jin Gao; Shun‐Guo Zhang is a Medicine article available to read on EtoBox.
What is Cost‐effectiveness analysis of dinutuximab β for the treatment of high‐risk neuroblastoma in China about?
## Abstract ## Background Dinutuximab β can be used to treat children with high‐risk neuroblastoma (NB). Due to its high price, whether dinutuximab β is cost‐effective for the treatment of high‐risk NB remains uncertain. Therefore, assessing the cost‐effectiveness of dinutuximab β in children with high‐risk NB is of high importance. ## Methods The health utilities and economic outcomes in children with high‐risk NB were projected using a partitioned survival model. The individual patient data (IPD) of add‐on treatment with dinutuximab β (GD2 group) were derived from the literature, while the IPD of traditional therapy (TT group) were obtained from retrospective data of Shanghai Children's Medical Center. Treatment costs included drugs, adverse event‐related expenses, and medical resource use. Utility values were obtained from the literature. Costs and quality‐adjusted life‐years (QALYs) were measured over a 10‐year time horizon. Deterministic sensitivity analyses (DSA) and probabilistic sensitivity analyses (PSA) were also conducted. ## Results Compared with the TT group, QALY increased in the GD2 group by 0.72 with an increased cost of $171,269.70, leading to an incremental cost‐e
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- Author
- An‐Le Shen; Jie Zhao; Li‐Ting Yu; An‐An Zhang; Bin Wu; Ye Fang; Ya‐Li Han; Chen‐Sui‐Zi Li; Zhi‐Ling Li; Yi‐Jin Gao; Shun‐Guo Zhang
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)