Can I read PD-L1 and the dawn of modern cancer immunotherapy on EtoBox?

PD-L1 and the dawn of modern cancer immunotherapy by Lieping Chen is a book available to read on EtoBox.

What is PD-L1 and the dawn of modern cancer immunotherapy about?

Nature Medicine, doi:10.1038/s41591-025-03698-4Lieping Chen ing and attacking cancer cells. This led me to proteins but that these proteins are rare in Department of Immunobiology, Dermatology, hypothesize that tumors expressed specific normal tissues. Later, this immunohistochemMedicine (Medical Oncology) and Yale proteins to disable immunity, whether generistry detection became a clinical standard as a Cancer Center, Yale University School of predictive biomarker for malignant tumors3.ated naturally or induced by therapy. This idea Medicine, New Haven, CT, USA. faced skepticism. Critics noted that late-stage Subsequent studies identified IFNγ as a e-mail: [email protected] contain countless molecular changes, major cytokine responsible for PD-L1 inducmaking a single immune-evasion mechanism tion, leading to the adaptive resistance hypoPublished online: xx xx xxxxthesis3. This hypothesis proposes that PD-L1 improbable — a concern still echoed today.ReferencesAs someone steeped in Darwinian princiis upregulated by tumor-infiltrating T cells 1. Dong, H., Zhu, G., Tamada, K. & Chen, L. Nat. Med. 5, ples, I saw tumors differently. Immune presthat secrete IFNγ upon recognition o

Author

Lieping Chen

Publisher

×

Published

2025

Language

EN