Opening book details…
Can I read Excessive Lysosomal Ion-trapping of Hydroxychloroquine and Azithromycin on EtoBox?
Excessive Lysosomal Ion-trapping of Hydroxychloroquine and Azithromycin by Derendorf, Hartmut is a Medicine article available to read on EtoBox.
What is Excessive Lysosomal Ion-trapping of Hydroxychloroquine and Azithromycin about?
A recent report identified significant reductions or disappearance of viral load in COVID-19 patients given a combination of hydroxychloroquine and azithromycin. The present communication discusses some common pharmacokinetic properties of these two drugs that may be linked to a potential underlying mechanism of action for these antiviral effects. The physicochemical properties of both hydroxychloroquine and azithromycin are consistent with particularly high affinity for the intracellular lysosomal space, which has been implicated as a target site for antiviral activity. The properties of both drugs predict dramatic accumulation in lysosomes, with calculated lysosomal drug concentrations that exceed cytosolic and extracellular concentrations by more than 50 000-fold. These predictions are consistent with previously reported experimentally measured cellular and extracellular concentrations of azithromycin. This is also reflected in the very large volumes of distribution of these drugs, which are among the highest of all drugs currently in use. The combination of hydroxychloroquine and azithromycin produces very high local concentrations in lysosomes. The clinical significance of thi
Who reads Excessive Lysosomal Ion-trapping of Hydroxychloroquine and Azithromycin?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Derendorf, Hartmut
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0924-8579)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)