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The association of cemiplimab plus sonidegib for synchronous cutaneous squamous cell carcinoma and basal cell carcinoma of the head and neck: Two case reports by Elena Colombo; Cristina Gurizzan; Arianna Ottini; Francesca Caspani; Cristiana Bergamini; Laura D. Locati; Chiara Marchiselli; Andrea Alberti; Luigi Lorini; Lisa F. Licitra; Paolo Bossi; Carlo Resteghini is a Medicine article available to read on EtoBox.
What is The association of cemiplimab plus sonidegib for synchronous cutaneous squamous cell carcinoma and basal cell carcinoma of the head and neck: Two case reports about?
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequent cancers in humans, with cumulative ultraviolet radiation exposure, aging, and immunodepression as the main risk factors. In most cases, these malignancies arise in the head and neck area, and they can be treated with locoregional therapies. A minority of cases require systemic therapy. Currently, Sonic Hedgehog inhibitors (i.e., vismodegib and sonidegib) have been approved for advanced BCC, while the PD-1 checkpoint inhibitor cemiplimab has been approved as a first-line treatment for cSCC and as a second-line treatment for BCC. Nevertheless, there is a clinical need for an effective and safe systemic therapies for advanced synchronous (syn) BCC/cSCC not amenable to local treatments. International guidelines do not provide specific recommendations for patients affected by this condition, and no case reports on the full-dose association of these medications have been previously reported. Here, we present the cases of two elderly patients affected by synBCC/cSCC of the head and neck, who received combined therapy with cemiplimab and sonidegib at full dose and standard schedule, achieving rema
Who reads The association of cemiplimab plus sonidegib for synchronous cutaneous squamous cell carcinoma and basal cell carcinoma of the head and neck: Two case reports?
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- Author
- Elena Colombo; Cristina Gurizzan; Arianna Ottini; Francesca Caspani; Cristiana Bergamini; Laura D. Locati; Chiara Marchiselli; Andrea Alberti; Luigi Lorini; Lisa F. Licitra; Paolo Bossi; Carlo Resteghini
- Publisher
- Frontiers Media SA
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)