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Effect of a short course of neoadjuvant hormonal therapy on the response to subsequent androgen suppression in prostate cancer patients with relapse after radiotherapy: A secondary analysis of the randomized protocol RTOG 86-10 by William U Shipley; J.D Lu; Michael V Pilepich; Kateri Heydon; Mack Roach III; Harvey B Wolkov; William T Sause; Philip Rubin; Colleen A Lawton; Mitchell Machtay is a Medicine article available to read on EtoBox.

What is Effect of a short course of neoadjuvant hormonal therapy on the response to subsequent androgen suppression in prostate cancer patients with relapse after radiotherapy: A secondary analysis of the randomized protocol RTOG 86-10 about?

## Purpose: To compare, by a secondary analysis, the therapeutic benefits of androgen suppression in protocol prostate cancer patients with relapse after radiotherapy (rt) for locally advanced disease who, in the phase iii trial beginning in 1987, were assigned to receive or not receive a short course of neoadjuvant maximal androgen suppression before definitive rt. ## Methods and materials: Between 1987 and 1991, 456 patients were entered in the radiation therapy oncology group trail 86-10 and randomized to receive (arm i) or not to receive (arm ii) neoadjuvant hormonal therapy (ht), which was 4 months of goserelin (3.6 mg every 4 weeks) and flutamide (250 mg t.i.d.) before and during rt for bulky t2-t4 tumors. the overall and disease-specific survival after both randomization and salvage ht for patients with relapse was evaluated, as well as the duration of response in those patients undergoing salvage ht. the outcomes in patients who had received neoadjuvant ht vs. those who had not were compared. the median follow-up after randomization for all alive patients was 9.0 years and was 5.5 years for alive patients after beginning salvage ht. ## Results: Fewer patients received salva

Who reads Effect of a short course of neoadjuvant hormonal therapy on the response to subsequent androgen suppression in prostate cancer patients with relapse after radiotherapy: A secondary analysis of the randomized protocol RTOG 86-10?

Author

William U Shipley; J.D Lu; Michael V Pilepich; Kateri Heydon; Mack Roach III; Harvey B Wolkov; William T Sause; Philip Rubin; Colleen A Lawton; Mitchell Machtay

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2002

Language

EN

Field

Medicine (Health Sciences)