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Can I read Current Topics in Microbiology and Immunology, Volume 296, Molecular Mimicry: Infection Inducing Autoimmune Disease, 1st Edition on EtoBox?
Current Topics in Microbiology and Immunology, Volume 296, Molecular Mimicry: Infection Inducing Autoimmune Disease, 1st Edition by Michael B.A. Oldstone (Editor) is a nonfiction available to read on EtoBox.
What is Current Topics in Microbiology and Immunology, Volume 296, Molecular Mimicry: Infection Inducing Autoimmune Disease, 1st Edition about?
The conceptual basis for molecular mimicry was first defined in the early 1980s when monoclonal antibodies against viruses were also shown to react with non-viral host protein; in this case, measles virus phosphoprotein cross-reacted with host cell cytokeratin, herpes simplex virus type 1 with host-cell vimentin and vaccinia virus with host-cell intermediate filaments. Following this discovery, others emerged, again at the clonal level, that T cell clones against proteins from a variety of infectious agents also reacted with host antigenic determinants. The clonal distinction was imperative for the initial definition of mimicry. At least 30 years prior to our initial description of molecular mimicry involving cross-reactions between numerous microbes, on the polyclonal antibody level, streptococcus was believed to react with renal glomeruli, heart and basal ganglia to account for the glomerulonephritis, heart and valvular disease and chorea, respectively. However, subsequent research showed that the nephritis was caused by immune complex deposits and the tissue damage they produced. Later, in 1990, the cross-reactivity of streptococcal antigen with myocardial antigens on a clonal l
Who reads Current Topics in Microbiology and Immunology, Volume 296, Molecular Mimicry: Infection Inducing Autoimmune Disease, 1st Edition?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Michael B.A. Oldstone (Editor)
- Publisher
- Springer-Verlag Berlin Heidelberg
- Published
- 2005
- Language
- EN
- ISBN
- 9783540255970
- Category
- nonfiction
- Subjects
- Medical, Science, Chemistry
Other editions & translations
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