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Can I read Investigation of the Metabolic Fate of 2‐, 3‐ and 4‐Bromobenzoic Acids in Bile‐duct‐cannulated Rats by Inductively Coupled Plasma Mass Spectrometry and High‐performance Liquid Chromatography/inductively Coupled Plasma Mass Spectrometry/electrospray Mass Spectrometry on EtoBox?
Investigation of the Metabolic Fate of 2‐, 3‐ and 4‐Bromobenzoic Acids in Bile‐duct‐cannulated Rats by Inductively Coupled Plasma Mass Spectrometry and High‐performance Liquid Chromatography/inductively Coupled Plasma Mass Spectrometry/electrospray Mass Spectrometry by Berit Packert Jensen; Christopher J. Smith; Christopher J. Bailey; Colin Rodgers; Ian D. Wilson; Jeremy K. Nicholson is a Chemistry article available to read on EtoBox.
What is Investigation of the Metabolic Fate of 2‐, 3‐ and 4‐Bromobenzoic Acids in Bile‐duct‐cannulated Rats by Inductively Coupled Plasma Mass Spectrometry and High‐performance Liquid Chromatography/inductively Coupled Plasma Mass Spectrometry/electrospray Mass Spectrometry about?
## Abstract Inductively coupled plasma mass spectrometry (ICPMS) has been used to determine the rate and routes of excretion of bromine following the intraperitoneal administration (50 mg kg^−1^) of 2‐, 3‐ and 4‐bromobenzoic acids to male bile‐duct‐cannulated rats. Analysis of urine and bile for ^79/81^Br using ICPMS showed that all three bromobenzoic acids were rapidly excreted (82–98%) within 48 h of dosing, primarily via the urine. High‐performance liquid chromatography/inductively coupled plasma mass spectrometry (HPLC/ICPMS) was then used to obtain metabolite profiles for bile and urine. These profiles revealed that extensive metabolism had taken place, with the unchanged bromobenzoic acids forming a minor part of the total of compound‐related material detected. Concomitant MS studies, supplemented by alkaline hydrolysis, enabled the identification of the major metabolite of all three of the bromobenzoic acids as a glycine conjugate. Ester glucuronide conjugates were also identified, but formed only a small proportion of total. Copyright © 2005 John Wiley & Sons, Ltd.
Who reads Investigation of the Metabolic Fate of 2‐, 3‐ and 4‐Bromobenzoic Acids in Bile‐duct‐cannulated Rats by Inductively Coupled Plasma Mass Spectrometry and High‐performance Liquid Chromatography/inductively Coupled Plasma Mass Spectrometry/electrospray Mass Spectrometry?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Berit Packert Jensen; Christopher J. Smith; Christopher J. Bailey; Colin Rodgers; Ian D. Wilson; Jeremy K. Nicholson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)