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Synthesis and Degradation of Sodium Iron Phosphate Glasses and Their in Vitro Cell Response by A. J. Parsons; M. Evans; C. D. Rudd; C. A. Scotchford is a Medicine article available to read on EtoBox.

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## Abstract The degradation profiles of six sodium iron phosphate glass formulations have been investigated using simple dissolution trials in deionized water. The glasses were produced from the appropriate phosphate salts by melting at 1200°C in 5% Au/95% Pt crucibles. Dissolution rates varied from 0.2 gcm^−2^h^−1^ for the 1% Fe glass to essentially zero over the 6‐week test period for the 15% Fe and 20% Fe glasses. The overall degradation rate was found to vary according to the approximate relation: rate = 1.3e^−0.79__x__^ gcm^−2^h^−1^, where __x__ is the percentage iron content of the glass. Glasses with 10% or greater iron content were observed to maintain a constant density over the course of the tests and thus appeared to degrade from the surface and not the bulk. __In vitro__ cell response tests were conducted on the glasses using macrophages and primary craniofacial osteoblasts. These tests were performed on the glasses with 10% or greater iron content because glasses with lower iron content degraded too quickly. Confocal microscopy revealed a rounded macrophage morphology and IL‐1β production was low, suggesting little macrophage activation. However, a significant level of

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Author

A. J. Parsons; M. Evans; C. D. Rudd; C. A. Scotchford

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2004

Language

EN

Field

Medicine (Health Sciences)