Can I read Linkage study of Catechol-O-Methyltransferase and attention-deficit hyperactivity disorder on EtoBox?
Linkage study of Catechol-O-Methyltransferase and attention-deficit hyperactivity disorder by Barr, Cathy L.; Wigg, Karen; Malone, Molly; Schachar, Russell; Tannock, Rosemary; Roberts, Wendy; Kennedy, James L. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Linkage study of Catechol-O-Methyltransferase and attention-deficit hyperactivity disorder about?
Attention-deficit hyperactivity disorder is the most common child psychiatric disorder with a prevalence rate in an Ontario study of 9% in boys and 3% in girls [Szatmari et al., 1989]. This disorder is characterized by problems in the areas of attention, overactivity, impulse control, and distractibility. Strong evidence for a genetic component has been provided from twin, family, and adoption studies [for review see Levy et al., 1998] and molecular genetic studies are in progress by several groups worldwide. The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD. In addition, children with velocardio-facial syndrome, a deletion syndrome of the chromosomal region 22q11 where the COMT gene has been localized, often have symptoms of ADHD suggesting this gene may have an etiological role in ADHD. In this study, we have tested for linkage in ADHD families using the functional polymorphism at codon 158 that determines COMT activity [Lachman et al., 1996] and analyzed the data with the transmission disequilibrium test (TDT). A total o
Who reads Linkage study of Catechol-O-Methyltransferase and attention-deficit hyperactivity disorder?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Barr, Cathy L.; Wigg, Karen; Malone, Molly; Schachar, Russell; Tannock, Rosemary; Roberts, Wendy; Kennedy, James L.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)