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Neurochemicals of limbic system and thalamofrontal cortical network: Are they different between patients with idiopathic generalized epilepsy and psychogenic nonepileptic seizure? by Leila Simani; Samira Raminfard; Marjan Asadollahi; Mehrdad Roozbeh; Fari Ryan; Mohammad Rostami is a Medicine article available to read on EtoBox.
What is Neurochemicals of limbic system and thalamofrontal cortical network: Are they different between patients with idiopathic generalized epilepsy and psychogenic nonepileptic seizure? about?
## Objective: Thalamofrontal cortical network and limbic system are proposed to be involved in psychogenic nonepileptic seizure (pnes) and idiopathic generalized epilepsy (ige). this study aimed to investigate neurochemical changes in prefrontal cortex, thalamus, and limbic circuits in patients with pnes and ige. we also analyzed the interaction between cognitive functions and neurochemical changes in both groups. ## Methods: Hydrogen proton magnetic resonance spectroscopy (1h-mrs) was used to measure n-acetyl aspartate (naa), choline (cho), creatine (cr), glutamate-glutamine (glx), and myo-inositol (mi). the voxels were placed on the bilateral dorsolateral prefrontal cortex (dlpfc), dorsomedial prefrontal cortex (dmpfc), anterior cingulate cortex (acc), and thalamus. attention and inhibitory control, as well as general intelligence status, were investigated using the integrated visual and auditory continuous performance test (iva-cpt) and the wechsler adult intelligence scale (wais), respectively, in patients with pnes and ige, as well as healthy volunteers. ## Results: The 1h-mrs showed a decreased ratio of naa/cr in the right and left thalamus, right dmpfc, and right acc in pati
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- Author
- Leila Simani; Samira Raminfard; Marjan Asadollahi; Mehrdad Roozbeh; Fari Ryan; Mohammad Rostami
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)