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GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos by Kim E Haworth; Surendra Kotecha; Timothy J Mohun; Branko V Latinkic is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background GATA factors 4/5/6 have been implicated in the development of the heart and endodermal derivatives in vertebrates. Work in zebrafish has indicated that GATA5 is required for normal development earlier than GATA4/6. However, the GATA5 knockout mouse has no apparent embryonic phenotype, thereby questioning the importance of the gene for vertebrate development. ## Results In this study we show that in __Xenopus__ embryos GATA5 is essential for early development of heart and liver precursors. In addition, we have found that in __Xenopus__ embryos GATA4 is important for development of heart and liver primordia following their specification, and that in this role it might interact with GATA6. ## Conclusion Our results suggest that GATA5 acts earlier than GATA4 to regulate development of heart and liver precursors, and indicate that one early direct target of GATA5 is homeobox gene Hex.

Who reads GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos?

Author

Kim E Haworth; Surendra Kotecha; Timothy J Mohun; Branko V Latinkic

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-213X)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)