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High Expression of Truncated GLI3 is Associated with Poor Overall Survival in Patients with Non-Small-Cell Lung Cancer by Bai, X.-Y.; Lin, J.-Y.; Zhang, X.-C.; Xie, Z.; Yan, H.-h.; Chen, Z.-H.; Xu, C.-R.; An, S.-J.; Sheng, G.-M.; Wu, Y.-L. is a Medicine article available to read on EtoBox.
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patients (P = 0.039). Multivariate analyses proved the status of KRAS mutation was an independent prognostic factor (HR = 2.69, 95% CI: 1.91-3.80, P = 0.0005). No difference was found in PFS and tumor response between the first-or second-line EGFR-TKI-treated patients harboring KRAS mutation and KRAS/EGFR wild-type (the first line: P = 0.23, 0.82; the second line: P = 1.00, 0.48). In the first-and second-line chemotherapy, there was no significant difference for PFS among the three groups (P = 0.15, 0.52). Conclusions: KRAS mutation was a poor prognosis factor, but not an independent predictive factor for EGFR-TKI and chemotherapy in lung cancer patients. EGFR wild-type is major reason for resistant to EGFR-TKI in patients with KRAS mutation.
Who reads High Expression of Truncated GLI3 is Associated with Poor Overall Survival in Patients with Non-Small-Cell Lung Cancer?
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- Author
- Bai, X.-Y.; Lin, J.-Y.; Zhang, X.-C.; Xie, Z.; Yan, H.-h.; Chen, Z.-H.; Xu, C.-R.; An, S.-J.; Sheng, G.-M.; Wu, Y.-L.
- Publisher
- Oxford University Press; Elsevier BV (ISSN 0923-7534)
- Published
- 2012
- Language
- EN
- Field
- Medicine (Health Sciences)