Can I read Myocardial Gap Junction Organization in Ischemia and Infarction on EtoBox?

Myocardial Gap Junction Organization in Ischemia and Infarction by Nicholas S. Peters is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Myocardial Gap Junction Organization in Ischemia and Infarction about?

Ischemia causes an increase in myocardial resistivity and a decrease in conduction velocity, thereby enhancing cardiac contractile dysfunction and arrhythmic tendency. Myocardial gap junctions, as principal determinants of conduction velocity, may, therefore, be expected to be deranged in ischemia. Despite a lack of consensus, attempts at correlating gap junction ultrastructural morphology with functional state have revealed the component connexons of gap junctions in freeze-fractured myocardium to be in multiple small hexagonal arrays, tending to become randomly distributed and compacted under uncoupling conditions. Further hypoxic uncoupling causes ultrastructural damage and a reduction in gap-junctional surface area. Immunohistochemical detection of connexin43 gap junctions in chronically ischemic non-infarcted human myocardium demonstrates a reduction in junctional surface area within a normal number of intercalated disks per myocyte, and with a normal distribution of junction sizes. In healed canine infarction there are smaller and fewer gap junctions in the fibrotic myocardium adjacent to infarcts, with reductions in overall gap-junctional content and the proportion of side-t

Who reads Myocardial Gap Junction Organization in Ischemia and Infarction?

Author

Nicholas S. Peters

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1059-910X)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)