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Cytochrome P450 monooxygenases play a crucial role in the oxidative biotransformation of xenobiotics during phase I drug metabolism, converting substrates into oxidized metabolites. These enzymes, primarily found in the liver, utilize molecular oxygen and NADPH to facilitate a variety of oxidative reactions, including aromatic hydroxylation, which is essential for the metabolism of many therapeutic agents. The document also discusses the potential toxicity of arene oxides formed during these reactions and t

Author

gakygollea

Language

EN