About this Engineering article

Chitosan/apatite composite beads prepared by in situ generation of apatite or Si-apatite nanocrystals by Natalia Davidenko; Raúl G. Carrodeguas; Carlos Peniche; Yaimara Solís; Ruth E. Cameron is a Engineering article available to read on EtoBox.

The objective of this work was to develop nanocrystalline apatite (Ap) dispersed in a chitosan (CHI) matrix as a material for applications in bone tissue engineering. CHI/Ap composites of different weight ratios (20/80, 50/50 and 80/20) and with CHI of different molecular weights were prepared by a biomimetic stepwise route. Firstly, CaHPO 4 Á2H 2 O (DCPD) crystals were precipitated from Ca(CH 3 COO) 2 and NaHPO 4 in the bulk CHI solution, followed by the formation of CHI/DCPD beads by coacervation. The beads were treated with Na 3 PO 4 /Na 5 P 3 O 10 solution (pH 12-13) to crosslink the CHI and to hydrolyse the DCPD to nanocrystalline Ap. This new experimental procedure ensured that complete conversion of DCPD into sodium-substituted apatite was achieved without appreciable increases in its crystallinity and particle size. In addition, composites with silicon-doped Ap were prepared by substituting Na 3 PO 4 by Na 2 SiO 3 in the crosslinking/hydrolysis step. Characterization of the resultant composites by scanning electron microscopy, X-ray powder diffraction (XRD), thermal analysis and Fourier transform infrared spectroscopy confirmed the formation, within the CHI matrix, of nanop

Author

Natalia Davidenko; Raúl G. Carrodeguas; Carlos Peniche; Yaimara Solís; Ruth E. Cameron

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)