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Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription by Jiawen Zhou; Haiyun Chen; Qiuyi Wang; Sihan Chen; Rong Wang; Ziyang Wang; Cuicui Yang; Ao Chen; Jingyu Zhao; Zihao Zhou; Zhiyuan Mao; Guoping Zuo; Dengshun Miao; Jianliang Jin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription about?
## Abstract Determining the mechanism of senescence‐associated pulmonary fibrosis is crucial for designing more effective treatments for chronic lung diseases. This study aimed to determine the following: whether Sirt1 and serum vitamin D decreased with physiological aging, promoting senescence‐associated pulmonary fibrosis by activating TGF‐β1/IL‐11/MEK/ERK signaling, whether Sirt1 overexpression prevented TGF‐β1/IL‐11/MEK/ERK signaling‐mediated senescence‐associated pulmonary fibrosis in vitamin D‐deficient (Cyp27b1^−/−^) mice, and whether Sirt1 downregulated IL‐11 expression transcribed by TGF‐β1/Smad2 signaling through deacetylating histone at the IL‐11 promoter in pulmonary fibroblasts. Bioinformatics analysis with RNA sequencing data from pulmonary fibroblasts of physiologically aged mice was conducted for correlation analysis. Lungs from young and physiologically aged wild‐type (WT) mice were examined for cell senescence, fibrosis markers, and TGF‐β1/IL‐11/MEK/ERK signaling proteins, and 1,25(OH)~2~D~3~ and IL‐11 levels were detected in serum. Nine‐week‐old WT, Sirt1 mesenchymal transgene (Sirt1^Tg^), Cyp27b1^−/−^, and Sirt1^Tg^Cyp27b1^−/−^ mice were observed the pulmonary f
Who reads Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jiawen Zhou; Haiyun Chen; Qiuyi Wang; Sihan Chen; Rong Wang; Ziyang Wang; Cuicui Yang; Ao Chen; Jingyu Zhao; Zihao Zhou; Zhiyuan Mao; Guoping Zuo; Dengshun Miao; Jianliang Jin
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)