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CDKN2A/B deletions are strongly associated with meningioma progression: a meta-analysis of individual patient data by Wach, Johannes (author);Basaran, Alim Emre (author);Arlt, Felix (author);Vychopen, Martin (author);Seidel, Clemens (author);Barrantes-Freer, Alonso (author);Müller, Wolf (author);Gaunitz, Frank (author);Güresir, Erdem (author) is a Medicine article available to read on EtoBox.

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Homozygous CDKN2A/B deletion has been associated with an increased risk of recurrence in meningiomas. However, the evidence is confined to a limited number of studies, and the importance of heterozygous CDKN2A/B deletions remains insufficiently investigated. Hence, the present meta-analysis reconstructs individual patient data (IPD) and reconstructs the probabilities of progression-free survival (PFS) stratified by CDKN2A/B status. IPD of PFS rates were extracted from published Kaplan–Meier plots using the R package __IPDfromKM__ in R studio (RStudio, Boston, MA, USA). Reconstructed Kaplan–Meier Plots of the pooled IPD data were created. One-stage and two-stage meta-analyses were performed. Hazard ratios (HR) were used as effective measures. Of 181 records screened, four articles with 2521 participants were included. The prevalence of homozygous CDKN2A/B deletions in the included studies was 0.049 (95% CI 0.040–0.057), with higher tumor grades associated with a significantly greater proportion of CDKN2A/B deletions. The reconstructed PFS curves for the pooled cohort showed that the median PFS time of patients with a CDKN2A/B wild-type status, heterozygous or homozygous CDKN2A/B del

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Author

Wach, Johannes (author);Basaran, Alim Emre (author);Arlt, Felix (author);Vychopen, Martin (author);Seidel, Clemens (author);Barrantes-Freer, Alonso (author);Müller, Wolf (author);Gaunitz, Frank (author);Güresir, Erdem (author)

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)