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Can I read Binding of Antibodies in Liposomes to Extracellular Matrix Antigens on EtoBox?
Binding of Antibodies in Liposomes to Extracellular Matrix Antigens by V. P. Torchilin; A. L. Klibanov; N. N. Ivanov; M. A. Gluckhova; V. E. Koteliansky; H. K. Kleinman; G. R. Martin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Binding of Antibodies in Liposomes to Extracellular Matrix Antigens about?
We have incorporated antibodies against fibronectin or laminin into liposomes and studied their interaction with insoluble forms of these antigens. The antibodies, after modification by palmitoylchloride, were incorporated into the lipid bilayer by the cholate dialysis method. The antibodies in the liposomes recognized their specific antigen with little reaction to the alternative attachment protein or to albumin (< 2%). The binding of antibody-containing liposomes to insoluble antigen was inhibited by soluble antibodies to the respective antigens but not by antibodies to other antigens. The affinity constant of the liposome-antibody complex with the antigen was estimated at 1-10 X M liposomes. Thus, antibodies in liposomes retain their reactivity and specificity, and the reaction constant is comparable to that observed for immune complexes.
Who reads Binding of Antibodies in Liposomes to Extracellular Matrix Antigens?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- V. P. Torchilin; A. L. Klibanov; N. N. Ivanov; M. A. Gluckhova; V. E. Koteliansky; H. K. Kleinman; G. R. Martin
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)
- Published
- 1985
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)