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The Pharmacokinetics of Erythropoietin in the Cerebrospinal Fluid After Intravenous Administration of Recombinant Human Erythropoietin by Anargyros Xenocostas; Wing K. Cheung; Francis Farrell; Cindy Zakszewski; Marian Kelley; Andrzej Lutynski; Michael Crump; Jeffrey H. Lipton; Thomas L. Kiss; Catherine Y. Lau; Hans A. Messner is a Medicine article available to read on EtoBox.
What is The Pharmacokinetics of Erythropoietin in the Cerebrospinal Fluid After Intravenous Administration of Recombinant Human Erythropoietin about?
Objectives: Erythropoietin (EPO) was originally described as a regulator of erythropoiesis. Recently, synthesis of EPO and expression of the EPO receptor (EPO-R) have been reported for the central nervous system (CNS). The potential use of EPO to prevent or reduce CNS injury and the paucity of information regarding its entry into the human CNS led us to examine the pharmacokinetics (PK) of recombinant human EPO (r-HuEPO) in the serum and cerebrospinal fluid (CSF). Methods: Four patients with Ommaya reservoirs were enrolled to facilitate serial CSF sampling. R-HuEPO was given intravenously (IV) in single doses of 40,000 IU or 1,500 IU/kg and in multiple doses of 40,000 IU daily for 3 days. Results: The EPO concentrations in the CSF increased after a period of slow equilibration. Linear first-order distribution kinetics were observed for serum and CSF. The concentration of EPO in the CSF was proportional to the serum concentration of EPO and the permeability of the blood-brain barrier (BBB), as determined by the albumin quotient (Q A =[albumin] CSF/[albumin] ser-um). A rise in the CSF concentration was seen as early as 3 h after IV administration. Peak levels (C max ) were reached be
Who reads The Pharmacokinetics of Erythropoietin in the Cerebrospinal Fluid After Intravenous Administration of Recombinant Human Erythropoietin?
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- Author
- Anargyros Xenocostas; Wing K. Cheung; Francis Farrell; Cindy Zakszewski; Marian Kelley; Andrzej Lutynski; Michael Crump; Jeffrey H. Lipton; Thomas L. Kiss; Catherine Y. Lau; Hans A. Messner
- Publisher
- Springer Science and Business Media LLC
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)