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Evaluation on testing of deep throat saliva and lower respiratory tract specimens with Xpert Xpress SARS-CoV-2 assay by River Chun-Wai Wong; Ann Han Wong; Yolanda Iok-Ieng Ho; Eddie Chi-Man Leung; Raymond Wai-Man Lai is a Medicine article available to read on EtoBox.

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## Background: Xpert® xpress sars-cov-2 assay is only validated on nasopharyngeal specimens for detection of sars-cov-2. other specimen types such as deep throat saliva (dts), also known as posterior oropharyngeal saliva and lower-respiratorytract specimens (lrt) including sputum, tracheal aspirate and bronchoalveolar lavage are not validated. these non-validated specimen types, however, do have significant diagnostic value. ## Objective: Evaluate the performance of xpert xpress sars-cov-2 assay for detection of sars-cov-2 from dts and lrt specimens. ## Methods: 162 specimens from 158 patients with suspected covid-19 disease were tested with xpert xpress sars-cov-2 assay. these included 120 dts and 42 lrt specimens i.e. 35 sputum, 6 tracheal aspirate and one bronchoalveolar lavage. results were compared to those by the tib-molbiol lightmix® sarbecov e-gene assay. ## Results: Xpert xpress sars-cov-2 assay has satisfactory performance when compared with reference method. the positive percent agreement (ppa) of dts and lrt specimens were 98.86 % & 100 % respectively while the negative percent agreement (npa) was 100 % for both dts and lrt specimens. ## Conclusions: This study demonstr

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Author

River Chun-Wai Wong; Ann Han Wong; Yolanda Iok-Ieng Ho; Eddie Chi-Man Leung; Raymond Wai-Man Lai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1386-6532)

Published

2020

Language

EN

Field

Medicine (Health Sciences)