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Impact of short-term glycemic variability on risk of all-cause mortality in type 2 diabetes patients with well-controlled glucose profile by continuous glucose monitoring: A prospective cohort study by Yifei Mo; Chunfang Wang; Jingyi Lu; Yun Shen; Lei Chen; Lei Zhang; Wei Lu; Wei Zhu; Tian Xia; Jian Zhou is a Medicine article available to read on EtoBox.

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## Aims: To investigate the association between short-term glycemic variability (gv) and all-cause mortality in type 2 diabetes with well-controlled glucose profile by continuous glucose monitoring (cgm). ## Methods: In this prospective study, 1839 diabetes patients who reached percentage of time in the target glucose range of 3.9-10 mmol/l > 70%, percentage of time above range of 10 mmol/l < 25% and percentage of time below range of 3.9 mmol/l 35%. cox proportional hazard models were used to estimate hazard ratios (hrs) of all-cause mortality risk associated with the different %cv categories. ## Results: At baseline, participants had mean age of 60.9 years and mean hba of 7.3% (56 mmol/mol). a total of 165 deaths were identified during a median follow-up of 6.9 years. in multivariate cox regression analysis, hrs associated with %cv categories were 1.00, 1.16 (95% ci 0.78-1.73), 1.38 (95% ci 0.89-2.15), 1.33 (95% ci 0.77-2.29) and 2.26 (95% ci 1.13-4.52) for all-cause mortality. ## Conclusions: Greater %cv was associated with increased risk for all-cause mortality even among patients with seemingly well-controlled glucose status.

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Author

Yifei Mo; Chunfang Wang; Jingyi Lu; Yun Shen; Lei Chen; Lei Zhang; Wei Lu; Wei Zhu; Tian Xia; Jian Zhou

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)