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The role of microRNA-30c in targeting interleukin 6, as an inflammatory cytokine, in the mesenchymal stem cell: a therapeutic approach in colorectal cancer by Mohamad Mahjoor; Hamed Afkhami; Mohammad Najafi; Atieh Nasr; Samaneh Khorrami is a Medicine article available to read on EtoBox.

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## Introduction: Colorectal cancer (crc) is the third most prevalent cancer and the second significant cause of cancer-associated death worldwide. the microrna-30 is a substantial member of the mirna family and plays a vital role in expanding several cancers. this microrna potentially targets interleukin 6 as an inflammatory cytokine in crc. ## Materials and methods: Mscs were isolated and identified from mice bone marrow and then transduced with lentiviruses containing mir-30c. transfected mscs were collected to evaluate il-6 levels, ct-26 cells were also co-cultured with mscs, and the effect of apoptosis and il-6 on the supernatant was assessed. ## Results: Our result showed the expression of il-6 mrna and the level of protein were decreased in the supernatant of mir-30-transduced msc cells compared to the control group. in addition, the rate of apoptosis was assessed, and the obtained data revealed the induction of apoptosis in ct-26 cells when they are in the vicinity of mir-30c-transduced mscs. ## Discussion and conclusion: We demonstrated that downregulation of mir-30c was significantly correlated with crc progression and survival. so, the present study elucidated the antican

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Author

Mohamad Mahjoor; Hamed Afkhami; Mohammad Najafi; Atieh Nasr; Samaneh Khorrami

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)