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Risk of Stroke in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis by Zhilong Xiao; Zhimin Pei; Min Yuan; Xueli Li; Shenjian Chen; Lijun Xu is a Medicine article available to read on EtoBox.

What is Risk of Stroke in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis about?

## Objective: Observational studies, to date, have provided inconsistent findings on whether inflammatory bowel disease (ibd) is associated with an increased risk of stroke. we therefore performed a meta-analysis to evaluate the association of ibd and its specific subtypes with risk of stroke. ## Design: We searched electronic databases for studies through may 13, 2015 assessing risk of stroke in patients with ibd. cohort and case-control studies that reported incident cases of stroke in patients with ibd and a non-ibd control population were eligible. we calculated pooled hazard ratios (hrs) with 95% confidence intervals (cis). ## Results: A total of 8 articles (126,493 ibd patients and 4748 cases of stroke) were included in this meta-analysis. the presence of ibd revealed a trend toward a modest increase in the risk of stroke incidence (hr = 1.29; 95% ci, 1.16-1.43). after subgroup analysis, crohn's disease showed an increased risk of stroke incidence (7 studies: hr = 1.32; 95% ci, 1.13-1.56), and a significant association was also identified in ulcerative colitis (6 studies: hr = 1.18; 95% ci, 1.06-1.31). in addition, this risk is higher in women (6 studies: hr = 1.49; 95% ci, 1

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Author

Zhilong Xiao; Zhimin Pei; Min Yuan; Xueli Li; Shenjian Chen; Lijun Xu

Publisher

Elsevier BV

Published

2015

Language

EN

Field

Medicine (Health Sciences)