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Can I read Small Intestinal Microbial Dysbiosis Underlies Symptoms Associated with Functional Gastrointestinal Disorders on EtoBox?
Small Intestinal Microbial Dysbiosis Underlies Symptoms Associated with Functional Gastrointestinal Disorders by George B. Saffouri; Robin R. Shields-Cutler; Jun Chen; Yi Yang; Heather R. Lekatz; Vanessa L. Hale; Janice M. Cho; Eric J. Battaglioli; Yogesh Bhattarai; Kevin J. Thompson; Krishna K. Kalari; Gaurav Behera; Jonathan C. Berry; Stephanie A. Peters; Robin Patel; Audrey N. Schuetz; Jeremiah J. Faith; Michael Camilleri; Justin L. Sonnenburg; Gianrico Farrugia; Jonathan R. Swann; Madhusudan Grover; Dan Knights; Purna C. Kashyap is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Small Intestinal Microbial Dysbiosis Underlies Symptoms Associated with Functional Gastrointestinal Disorders about?
## Abstract Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in symptomatic patients and does not correspond with aspirate culture results. In a pilot interventional study we found that switching from a high fiber diet to a low fiber, high simple sugar diet triggered FGID-related symptoms and decreased small intestinal microbial diversity while increasing small intestinal permeability. Our findings demonstrate that characterizing small intestinal microbiomes in patients with gastrointestinal symptoms may allow a more targeted antibacterial or a diet-based approach to treatment.
Who reads Small Intestinal Microbial Dysbiosis Underlies Symptoms Associated with Functional Gastrointestinal Disorders?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- George B. Saffouri; Robin R. Shields-Cutler; Jun Chen; Yi Yang; Heather R. Lekatz; Vanessa L. Hale; Janice M. Cho; Eric J. Battaglioli; Yogesh Bhattarai; Kevin J. Thompson; Krishna K. Kalari; Gaurav Behera; Jonathan C. Berry; Stephanie A. Peters; Robin Patel; Audrey N. Schuetz; Jeremiah J. Faith; Michael Camilleri; Justin L. Sonnenburg; Gianrico Farrugia; Jonathan R. Swann; Madhusudan Grover; Dan Knights; Purna C. Kashyap
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)