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Histological Changes Associated with the Use of Intravenous Cyclosporin in the Treatment of Severe Ulcerative Colitis May Mimic Dysplasia by G. M. Hyde; D. P. Jewell; B. F. Warren is a Medicine article available to read on EtoBox.

What is Histological Changes Associated with the Use of Intravenous Cyclosporin in the Treatment of Severe Ulcerative Colitis May Mimic Dysplasia about?

## Abstract **Background** During six years experience of intravenous cyclosporin (iv Cy) for severe ulcerative colitis we have noted that changes of villous architecture and epithelial regeneration occur even when the disease fails to enter clinical remission and colectomy is required. **Objective** To describe the histological changes in patients who received iv Cy and steroids compared with those treated with iv steroids alone. **Patients and methods** Two groups of histological sections were reviewed. The first group was of 23 colectomy specimens from patients who had been treated with iv Cy and steroids. For 11 patients pre‐Cy histological sections were available. The second group was of 10 colectomy specimens from patients who had received iv steroids alone. Biopsies were scored for their histological disease activity (HDAI), villous architecture and epithelial regeneration. The HDAI assesses the degree of acute and chronic inflammation. **Results** The post‐Cy group had higher median scores for villous architecture and epithelial regeneration compared to the pre‐Cy and poststeroid groups. For the patients where both pre‐ and post‐Cy histological sections were available 63% i

Who reads Histological Changes Associated with the Use of Intravenous Cyclosporin in the Treatment of Severe Ulcerative Colitis May Mimic Dysplasia?

Author

G. M. Hyde; D. P. Jewell; B. F. Warren

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1462-8910)

Published

2002

Language

EN

Field

Medicine (Health Sciences)