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Loneliness and Risk of Parkinson Disease by Antonio Terracciano; Martina Luchetti; Selin Karakose; Yannick Stephan; Angelina R. Sutin is a Medicine article available to read on EtoBox.

What is Loneliness and Risk of Parkinson Disease about?

## Importance Loneliness is associated with morbidity and mortality, including higher risk of neurodegenerative diseases. To our knowledge, no study has examined whether the association between loneliness and detrimental outcomes extends to Parkinson disease (PD). ## Objective To assess whether loneliness is associated with risk of incident PD and whether the association is independent of other risk factors or modified by age, sex, and genetic vulnerability. ## Design, Setting, and Participants This prospective cohort study included a population-based sample of UK Biobank participants aged 38 to 73 years with loneliness data and without a diagnosis of PD at baseline who were first assessed from March 13, 2006, to October 1, 2010, and followed up to October 9, 2021. ## Exposure Feeling lonely and covariates that are known risk factors for or prodromal features of PD. ## Main Outcome and Measure Incident PD was ascertained through UK National Health Service health records. ## Results Of 491 603 participants (mean [SD] age, 56.54 [8.09] years; 54.4% female), 2822 developed PD during the 15-year follow-up. Individuals who reported being lonely had a higher risk of PD (hazard ratio [HR]

Who reads Loneliness and Risk of Parkinson Disease?

Author

Antonio Terracciano; Martina Luchetti; Selin Karakose; Yannick Stephan; Angelina R. Sutin

Publisher

American Medical Association (AMA)

Published

2023

Field

Medicine (Health Sciences)