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Immunogenicity of polymeric implants: Long-term antibody response against polyester (Dacron) following the implantation of vascular prostheses into LEW.1A rats by M. Schlosser; L. Wilhelm; G. Urban; B. Ziegler; M. Ziegler; R. Zippel is a Medicine article available to read on EtoBox.

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## Abstract Implanted biomaterials trigger acute and chronic inflammatory responses directly correlated to the central role of phagocytic cells at the host–implant interface. This study was designed to evaluate specific humoral immune responses following repeated intraperitoneal implantations of collagen‐impregnated polyester (Dacron) prosthetic segments into LEWIS rats. Serum antibody detection was performed by enzyme immunoassay with the prosthetic segments as a target. Cutoff values for antibody positivity were greater than or equal to the 99th percentile for control rats. Polymer immunoglobiulin G (IgG) antibodies were significantly increased (__p__ < 0.05) by repeated implantation and were subsequently followed until experimental day 293. Antibody formation was significantly enhanced through the application of complete Freund's adjuvant in combination with the first implantation. All rats within this group were antibody‐positive on day 53, but only 6 of 10 animals that received the prosthesis without the adjuvant were. After preincubation of sera with bovine collagen type I (solid phase adsorbed or in solution), polymer antibody binding was discovered not to be diminished, ind

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Author

M. Schlosser; L. Wilhelm; G. Urban; B. Ziegler; M. Ziegler; R. Zippel

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2002

Language

EN

Field

Medicine (Health Sciences)