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Can I read Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked on EtoBox?
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked by Jie Yang; Xuesong Liu; Kapil Bhalla; Caryn Naekyung Kim; Ana Maria Ibrado; Jiyang Cai; Tsung-I Peng; Dean P. Jones; Xiaodong Wang is a Medicine article available to read on EtoBox.
What is Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked about?
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.
Who reads Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jie Yang; Xuesong Liu; Kapil Bhalla; Caryn Naekyung Kim; Ana Maria Ibrado; Jiyang Cai; Tsung-I Peng; Dean P. Jones; Xiaodong Wang
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Social Sciences)