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The Synergistic Anticancer Effect of Troglitazone Combined with Aspirin Causes Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells by Kun-Huang Yan; Chih-Jung Yao; Hwan-You Chang; Gi-Ming Lai; Ann-Lii Cheng; Shuang-En Chuang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Synergistic Anticancer Effect of Troglitazone Combined with Aspirin Causes Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells about?
## Abstract Troglitazone (TGZ) is a synthetic thiazolidinedione drug belonging to a group of potent peroxisome proliferator‐activated receptor γ (PPARγ) agonists known to inhibit proliferation, alter cell cycle regulation, and induce apoptosis in various cancer cell types. TGZ is an oral anti‐type II diabetes drug that can reverse insulin resistance. For more then 100 yr, aspirin, a nonselective cyclooxygenase (COX) inhibitor, has been successfully used as an anti‐inflammatory drug. Recently, Aspirin (ASA) and some other nonsteroidal anti‐inflammatory drugs (NSAIDs) have drawn much attention for their protective effects against colon cancer and cardiovascular disease; it has been observed that ASA's anti‐tumor effect can be attributed to inhibition of cell cycle progression, induction of apoptosis, and inhibition of angiogenesis. In this report we demonstrate for the first time that, when administered in combination, TGZ and ASA can produce a strong synergistic effect in growth inhibition and G~1~ arrest in lung cancer CL1‐0 and A549 cells. Examination by colony formation assay revealed an even more profound synergy. In Western blot, combined TGZ and ASA also could downregulate Cdk
Who reads The Synergistic Anticancer Effect of Troglitazone Combined with Aspirin Causes Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kun-Huang Yan; Chih-Jung Yao; Hwan-You Chang; Gi-Ming Lai; Ann-Lii Cheng; Shuang-En Chuang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)