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Drug-induced and Postnatal Hypothyroidism Impairs the Accumulation of Diacylglycerol in Liver and Liver Cell Plasma Membranes by Oksana A Krasilnikova; Nataliya S Kavok; Nataliya A Babenko is a Medicine article available to read on EtoBox.

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## Background: Thyroid hormones are well known modulators of signal transduction. the effect of hyper- and hypo-thyroidism on diacylglycerol/protein kinase c (dag/pkc) signaling in cardiomiocytes has been determined. triiodothyronine (t3) has been shown to prevent the alpha1-adrenoreceptor-mediated activation of pkc but does not alter the stimulation of enzyme and hepatic metabolism by phorbol ethers. it has been suggested that the elevation of endogenous dag in senescent or hypothyroid cells changes the pkc-dependent response of cells to phorbol esters and hormones. in the present study, was examined the formation of dag and activation of pkc in liver cells from rats of different thyroid status. ## Results: The results obtained provide the first demonstration of dag accumulation in liver and cell plasma membranes at age- and drug-dependent thyroid gland malfunction. the experiments were performed in either the [14c]ch3cooh-labeled rat liver, liver slices or hepatocytes labeled by [14c] oleic acid and [3h]arachidonic acid or [14c]palmitic acid as well as in the isolated liver cell plasma membranes of 90- and 720-day-old rats of different thyroid status. the decrease of t4 and t3 le

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Author

Oksana A Krasilnikova; Nataliya S Kavok; Nataliya A Babenko

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1472-6793)

Published

2002

Language

EN

Field

Medicine (Life Sciences)