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Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome by M. Willems; L. Sheng; T. Roskams; B. Ramdani; J. M. Doutrelepont; F. Nevens; P. Durez; S. Treille; M. Adler; V. Desmet; J. Fevery; Prof. Dr. S. H. Yap is a Medicine article available to read on EtoBox.
What is Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome about?
## Abstract Recently, evidence has been presented for a possible association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). Eleven consecutive patients with EMC and two with cryoglobulinemia type I were examined for the presence of markers of HCV infection. Eleven of 13 patients (10 with EMC and 1 with type I cryoglobulinemia) had anti‐HCV antibodies (as determined by a second generation anti‐HCV assay) and HCV‐RNA in plasma or serum. HCV‐RNA was also detected in liver biopsies of five patients. Genotyping showed that HCV genotype 1 was found in 10 of 11 patients with HCV‐RNA (9 genotype 1b and 1 genotype 1a) and only one patient had HCV genotype 2. However, a similar high prevalence of genotype 1b (100%) was found in a group of 14 consecutive patients with chronic hepatitis C, who had no clinical evidence of cryoglobulinemia. Concomitant infection was present in three patients with genotypes 2, 3 and 4, respectively. These findings stress the high prevalence of HCV infection in patients with EMC and further study shows that a difference in genotype prevalence was not found between HCV‐related EMC and chronic hepatitis C without clinical manif
Who reads Hepatitis C virus and its genotypes in patients suffering from chronic hepatitis C with or without a cryoglobulinemia-related syndrome?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- M. Willems; L. Sheng; T. Roskams; B. Ramdani; J. M. Doutrelepont; F. Nevens; P. Durez; S. Treille; M. Adler; V. Desmet; J. Fevery; Prof. Dr. S. H. Yap
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)
- Published
- 1994
- Language
- EN
- ISBN
- 9781890440312
- Field
- Medicine (Health Sciences)