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Ouabain‐Induced Coronary Vasoconstriction In Cats Is Not Neurally Mediated by Balagopalan A Nair; Yasemin Z Murad; Michael J Brody; David D Gutterman is a Medicine article available to read on EtoBox.

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## SUMMARY 1. Previous reports indirectly implicate a neural mechanism for coronary constriction to centrally administered digitalis. However, autoregulatory changes in coronary resistance due to changes in arterial pressure may have influenced the interpretation of these studies. 2. We tested directly the hypothesis that cardiac sympathetic innervation is responsible for coronary constriction to ouabain by examining the effects of ouabain (intravenous (i.v.) and intracerebroventricular (i.c.v.)) before and after bilateral stellate ganglionectomy. 3. Cats were anaesthetized and instrumented for the measurement of heart rate, blood pressure and coronary blood flow velocity using an epicardial‐attached suction Doppler probe. Animals were treated with atenolol and the effects of either i.v. or i.c.v. injections of ouabain were examined. 4. In seven cats treated with atenolol, i.v. ouabain (0.11 mg/kg) produced maximal increases in arterial pressure and coronary vascular resistance index (CVRI) of 66 ± 7 mmHg and 37 ± 9%, respectively. Following bilateral stellate ganglionectomy (__n__ = 7), ouabain produced similar increases in arterial pressure (70 ± 9 mmHg) and CVRI (39 ± 7%). A hig

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Author

Balagopalan A Nair; Yasemin Z Murad; Michael J Brody; David D Gutterman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0305-1870)

Published

2001

Language

EN

Field

Medicine (Health Sciences)