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Evaluation of Metal Complexation as an Alternative to Protonation for Electrospray Ionization of Pharmaceutical Compounds by Erwin J. Alvarez; Jennifer S. Brodbelt is a Chemistry article available to read on EtoBox.
What is Evaluation of Metal Complexation as an Alternative to Protonation for Electrospray Ionization of Pharmaceutical Compounds about?
The use of pyridyl and polyether compounds as auxiliary ligands to promote metal complexation of a series of pharmaceutical analytes by electrospray ionization (ESI) is explored as an alternative to conventional protonation by ESI. The auxiliary ligands vary in the number and nature of binding sites, the orientation of the binding sites with respect to each other, and the conformational flexibility of the ligand during complexation of the metal ion. The ESI of ternary solutions composed of a pharmaceutical substrate, a transition metal ion salt, and an auxiliary complexation agent generate metal complexes of the type [(L-H ϩ )M II (aux)] ϩ , where L is the pharmaceutical, M is either copper, nickel, or cobalt, and aux is the auxiliary ligand. Overall, the pyridine-type ligands are more useful for the generation of ternary metal complexes than the polyether-type ligands, which preferentially complex sodium ions and, upon collisional activation, undergo fragmentation of the polyether skeleton in addition to the structurally informative dissociation of the analytes. The auxiliary ligand that exhibits the best performance is 2,2Ј-dipyridine; its ternary metal complexes enhance the stru
Who reads Evaluation of Metal Complexation as an Alternative to Protonation for Electrospray Ionization of Pharmaceutical Compounds?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Erwin J. Alvarez; Jennifer S. Brodbelt
- Publisher
- Elsevier Science; Springer-Verlag; Springer New York LLC; American Chemical Society (ACS); Springer Science and Business Media LLC; Elsevier BV (ISSN 1044-0305)
- Published
- 1998
- Language
- EN
- Field
- Chemistry (Physical Sciences)