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Depression and fatigue in active IBD from a microbiome perspective—a Bayesian approach to faecal metagenomics by Anne Kerstin Thomann; Torsten Wüstenberg; Jakob Wirbel; Laura-Louise Knoedler; Philipp Arthur Thomann; Georg Zeller; Matthias Philip Ebert; Stefanie Lis; Wolfgang Reindl is a Medicine article available to read on EtoBox.

What is Depression and fatigue in active IBD from a microbiome perspective—a Bayesian approach to faecal metagenomics about?

## Background: Extraintestinal symptoms are common in inflammatory bowel diseases (ibd) and include depression and fatigue. these are highly prevalent especially in active disease, potentially due to inflammation-mediated changes in the microbiota-gut-brain axis. the aim of this study was to investigate the associations between structural and functional microbiota characteristics and severity of fatigue and depressive symptoms in patients with active ibd. ## Methods: We included clinical data of 62 prospectively enrolled patients with ibd in an active disease state. patients supplied stool samples and completed the questionnaires regarding depression and fatigue symptoms. based on taxonomic and functional metagenomic profiles of faecal gut microbiota, we used bayesian statistics to investigate the associative networks and triangle motifs between bacterial genera, functional modules and symptom severity of self-reported fatigue and depression. ## Results: Associations with moderate to strong evidence were found for 3 genera (odoribacter, anaerotruncus and alistipes) and 3 functional modules (pectin, glycosaminoglycan and central carbohydrate metabolism) with regard to depression and

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Author

Anne Kerstin Thomann; Torsten Wüstenberg; Jakob Wirbel; Laura-Louise Knoedler; Philipp Arthur Thomann; Georg Zeller; Matthias Philip Ebert; Stefanie Lis; Wolfgang Reindl

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)