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Within-host Spatial Dynamics of Viruses and Defective Interfering Particles by STEVEN A FRANK is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Within-host Spatial Dynamics of Viruses and Defective Interfering Particles about?

Defective-interfering (DI) viruses arise spontaneously by deletion mutations. The shortened genomes of the DI particles cannot replicate unless they coinfect a cell with a wild-type virus. Upon coinfection, the DI genome replicates more quickly and outcompetes the wild type. The coinfected cell produces mostly DI viruses. At the population level, the abundances of DI and wild-type viruses #uctuate dramatically under some conditions. In other cases, the DI viruses appear to mediate persistent infections with relatively low levels of host cell death. This moderation of viral damage has led some to suggest DI particles as therapeutic agents. Previous mathematical models have shown that either #uctuation or persistence can occur for plausible parameter values. I develop new mathematical models for the population dynamics of DI and wild-type viruses. My work extends the theory by developing speci"c predictions that can be tested in the laboratory. These predictions, if borne out by experiment, will explain the key processes that control the diversity of observed outcomes. The most interesting prediction concerns the rate at which killed host cells are replaced. A low rate of replacement

Who reads Within-host Spatial Dynamics of Viruses and Defective Interfering Particles?

Author

STEVEN A FRANK

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)