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This study developed a two-layer dissolving polymeric microneedle patch composed of gelatin and sodium carboxymethyl cellulose to deliver insulin transdermally for glucose regulation in diabetic mice. In vitro tests showed the microneedles successfully inserted into skin and insulin was gradually released. Ex vivo tests found 50% of insulin was released within 1 hour and 80% within 5 hours across skin. In vivo pharmacodynamic studies in diabetic mice demonstrated the microneedle patches achieved satisfactor

Author

CadR 1

Language

EN